Aller au contenu principal
A propos d'HEC A propos d'HEC Faculté et Recherche Faculté et Recherche Grande Ecole
& Masters Grande Ecole
& Masters
MBA Programs MBA Programs Programme PhD Programme PhD Executive Education Executive Education Summer School Summer School HEC Online HEC Online
A propos d'HEC En bref En bref Qui sommes-nous ? Qui sommes-nous ? Egalité des chances Egalité des chances HEC Talents HEC Talents International International Vie du campus Vie du campus Développement durable Développement durable Diversité et inclusion Diversité et inclusion Stories Stories Fondation HEC Fondation HEC Coronavirus Coronavirus Faculté et Recherche À propos À propos Corps professoral Corps professoral Départements Départements Centres Centres Chaires Chaires Knowledge Knowledge Grande Ecole
& Masters
Grande Ecole
Master in Management Grande Ecole
Master in Management
Master in International
Finance Master in International
Finance
MS
et Masters MS
et Masters
Programmes
X-HEC Programmes
X-HEC
Doubles Diplômes
en Admission directe Doubles Diplômes
en Admission directe
Visiting
students Visiting
students
Certificats Certificats Vie
Etudiante Vie
Etudiante
Student
Stories Student
Stories
MBA Programs MBA MBA Executive MBA Executive MBA TRIUM EMBA TRIUM EMBA Programme PhD Overview Overview HEC Difference HEC Difference Program details Program details Research areas Research areas HEC Community HEC Community Placement Placement Job Market Job Market Admissions Admissions Financing Financing Executive Education Executive Masters Executive Masters Certificats Executive Certificats Executive Programmes courts Executive Programmes courts Executive Online Online Entreprises Entreprises Executive MBA Executive MBA Infinity Pass Infinity Pass Summer School Youth programs Youth programs Summer programs Summer programs HEC Online En bref En bref Programme diplômant Programme diplômant Certificats Executive Certificats Executive MOOCs MOOCs Summer Programs Summer Programs
Faculté et Recherche

A Value-Based and Highly Sequential Approach to Learning in Clinical Trials

02 juin
2022
14H15
Jouy-en-Josas
Anglais

Participer

Ajouter au calendrier
2022-06-02T14:15:00 2022-06-02T15:30:00 A Value-Based and Highly Sequential Approach to Learning in Clinical Trials Information Systems and Operations Management (ISOM) Speaker : Stephen Chick  From : INSEAD Room: Bernard Ramanantsoa Jouy-en-Josas

Information Systems and Operations Management (ISOM)

Speaker : Stephen Chick 

From : INSEAD

Room: Bernard Ramanantsoa

"Clinical trials are necessary for evaluating the benefit of new health technologies but are quite costly, and have therefore been the subject of much study. This work explores the logical implication for clinical trial design of two important trends: (a) greater accountability in terms of cost and health benefits for new health technologies, and (b) adaptive clinical trial designs and advances in other sectors for highly sequential optimal learning. We propose and solve a Bayesian decision-theoretic model of a fully sequential experiment in which the end point is observed with delay, and where the trial design is based on health economic criteria rather than abstract statistical criteria. We identify sequential experiments which maximize the expected benefits of technology adoption decisions, minus sampling costs. The solution yields a unified policy defining the optimal `do not experiment'/`fixed sample size experiment'/`sequential experiment' regions and optimal stopping boundaries for sequential sampling, as a function of the prior mean benefit and the size of the delay. The model can value the expected benefits accruing to study units and the fixed costs of switching from control to treatment. We apply the model to the field of medical statistics, using data retrospectively from published trials from pragmatic trials in Europe, as well as for highly-sequential, highly multi-arm trial design for dose optimization. We highlight potential benefits of the approach."

Participer

Ajouter au calendrier
2022-06-02T14:15:00 2022-06-02T15:30:00 A Value-Based and Highly Sequential Approach to Learning in Clinical Trials Information Systems and Operations Management (ISOM) Speaker : Stephen Chick  From : INSEAD Room: Bernard Ramanantsoa Jouy-en-Josas